Learning and memory allow animals to adapt to dynamic environments, but how do different neural substrates contribute to these processes? How do molecular and physiological factors, along with individual differences, shape the acquisition and exploitation of knowledge? To explore these questions, I develop interpretable computational models grounded in theory and experimental data to explain and predict cognitive states and behaviors.
I am currently a Ph.D. student at the National University of Singapore, where I study biologically plausible models of spatial learning and associative memory under the supervision of Andrew Tan, Camilo Libedinsky, and Shih-Cheng Yen. Previously, I contributed to fMRI research on human memory with Gedi Lukšys and the monkey connectome with Anna Wang Roe.
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Shiqi Wang, Jiachuan Wang, Wenyuan Zhu, Yuchen Cheng, Beste Aydemir, Yanran Qiu, Wulfram Gerstner, Carmen Sandi, Gedi Luksys
Neuroscience 2023: Society for Neuroscience (SfN) 2023
We investigated how stress and uncertainty affect learning in two mouse strains using the Morris water maze and modeled their behavior with a biologically plausible network of border and place cells, revealing computational correlates of temperature-based differences.
Shiqi Wang, Jiachuan Wang, Wenyuan Zhu, Yuchen Cheng, Beste Aydemir, Yanran Qiu, Wulfram Gerstner, Carmen Sandi, Gedi Luksys
Neuroscience 2023: Society for Neuroscience (SfN) 2023
We investigated how stress and uncertainty affect learning in two mouse strains using the Morris water maze and modeled their behavior with a biologically plausible network of border and place cells, revealing computational correlates of temperature-based differences.
Xiangxing Kong, Xin Shu, Jiachuan Wang, Dandan Liu, Yingchun Ni, Weiqi Zhao, Lebo Wang, Zhihua Gao, Jiadong Chen, Bing Yang, Xing Guo, Zhiping Wang
Development 2022
The UBE4B-KLHL22 E3 ubiquitin ligase cascade regulates mTOR activity in neurodevelopment, and its disruption impairs neural precursor proliferation and differentiation, which can be rescued by mTOR inhibition.
Xiangxing Kong, Xin Shu, Jiachuan Wang, Dandan Liu, Yingchun Ni, Weiqi Zhao, Lebo Wang, Zhihua Gao, Jiadong Chen, Bing Yang, Xing Guo, Zhiping Wang
Development 2022
The UBE4B-KLHL22 E3 ubiquitin ligase cascade regulates mTOR activity in neurodevelopment, and its disruption impairs neural precursor proliferation and differentiation, which can be rescued by mTOR inhibition.